The Nest Unclutterer helps keep your Twitter account tidy.
You can clean your Twitter account by blocking accounts based on the number of users they themselves are following. In other words, that someone following hundreds or thousands of people is most likely a spammer, a bot, or both. You can also clean house by unfollowing users who haven’t tweeted in the last X number of days. Additionally, you can set a white list of user names to except from the filter.